FIG. 3.

ICP0 blocks virus-, IRF3-, and IRF7-mediated activation of ISG-specific promoters. Luciferase assays in 293 cells were used to measure activation of the RANTES (A) or IFN-β (B) promoters in response to infection with the paramyxovirus Sendai virus or expression of constitutively activated forms of IRF3 [IRF-3(5D)] and IRF7 [IRF-7(Δ247-467)] in the presence or absence of full-length ICP0. Results represent the mean ± standard deviation of three independent experiments.