Table 2.

Odds Ratios (OR) and 95% confidence interval (CI) for MCI and dementia for subjects with CES-D ≥ 4 from cross-sectional analyses using logistic regression. Model 1 is adjusted for age and gender; model 2 is additionally adjusted for education, ethnicity and APOE genotype; model 3 is additionally adjusted for vascular risk factors.

	At risk N	Cases N	Model 1 OR (95% CI)	Model 2* OR (95% CI)	Model 3** OR (95% CI)
MCI as outcome
All MCI (n=429)
No depression	1567	326	1	1	1
Depression	376	103	1.4 (1.1–1.9)	1.5 (1.1–1.9)	1.2 (0.9–1.7)
Amnestic MCI (n=222)
No depression	1383	174	1	1	1
Depression	314	48	1.3 (0.9–1.8)	1.3 (0.9–1.9)	1.0 (0.7–1.6)
Non Amnestic MCI (n=207)
No depression	1361	152	1	1	1
Depression	321	55	1.6 (1.2–2.3)	1.6 (1.1–2.4)	1.5 (1.0–2.2)
Dementia as outcome
All dementia (n=207)
No depression	1708	141	1	1	1
Depression	452	76	2.2 (1.6–3.1)	2.0 (1.4–2.9)	1.9 (1.3–2.9)
AD without vascular component (n=164)
No depression	1676	109	1	1	1
Depression	431	55	2.0 (1.4–2.9)	1.9 (1.3–3.1)	2.2 (1.3–3.5)
Vascular dementia including AD with stroke (n=33)
No depression	1588	21	1	1	1
Depression	388	12	2.5 (1.2–5.2)	2.0 (0.9–4.6)	1.2 (0.5–3.2)

^*based on a sample of 1645 subjects in whom APOE genotype was available.

^**based on a sample of 1399 subjects in whom the vascular risk score could be determined including all 5 risk factors;