Table 2.

Molar rotations of bistramide diastereomers.

Stereogenic segments composing bistramide			[M]D
C6–C11 THP/amide	C22–C31 Spiroketal	C34 ketone
(6S, 9R, 11R, 15S, 16R) [M]D = +119a	(22S, 23R, 27R, 31R) [M]D = −156	(34R) [M]D = −51	−88
		(34S) [M]D = +51d	+14
	(22R, 23S, 27S, 31S) [M]D = +156b	(34R) [M]D = −51	+224
		(34S) [M]D = +51d	+326
(6R, 9S, 11S, 15R, 16S) [M]D = −119	(22S, 23R, 27R, 31R) [M]D = −156	(34R) [M]D= −51	−326
		(34S) [M]D = +51d	−224
	(22R, 23S, 27S, 31S) [M]D = +156b	(34R) [M]D = −51	−14
		(34S) [M]D= +51d	+88

^asynthetic

^bderived from synthetic 78.

^cfrom normanicone (+)-79.