Table 2.
Association of discharge prescriptions for aldosterone antagonists with outcomes in propensity-matched inception cohort of older patients with heart failure and preserved ejection fraction (HF-PEF)
| Outcomes | Events (%) |
Absolute risk difference* |
Hazard ratio† (95% CI) |
P value | |
|---|---|---|---|---|---|
| Aldosterone antagonists | |||||
| New prescription | No (n=487) | Yes (n=487) | |||
| All-cause mortality or HF hospitalization | 393 (81%) | 392 (81%) | 0% | 0.97 (0.84–1.11) | 0.628 |
| All-cause mortality | 328 (67%) | 335 (69%) | +2% | 1.03 (0.89–1.20) | 0.693 |
| HF hospitalization | 219 (45%) | 199 (41%) | −4% | 0.88 (0.73–1.07) | 0.188 |
| All-cause hospitalization | 416 (85%) | 446 (92%) | +7% | 1.10 (0.96–1.26) | 0.156 |
| Any (new or continuation) prescription | No (n=712) | Yes (n=712) | |||
| All-cause mortality or HF hospitalization | 583 (82%) | 587 (82%) | 0% | 1.00 (0.89–1.12) | 0.991 |
| All-cause mortality | 502 (71%) | 492 (69%) | −2% | 0.94 (0.83–1.07) | 0.358 |
| HF hospitalization | 327 (46%) | 326 (46%) | 0% | 0.99 (0.85–1.16) | 0.918 |
| All-cause hospitalization | 616 (87%) | 639 (90%) | +3% | 1.06 (0.94–1.18) | 0.343 |
*
Absolute risk differences were calculated by subtracting percent events in patients not receiving aldosterone antagonists from those receiving those drugs
†
Hazard ratios comparing patients receiving aldosterone antagonists versus those not receiving those drugs