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. 2013 Mar 25;4(5):470–474. doi: 10.1021/ml3004507

Table 1. Percent Inhibition of Catalytic Activity for Different Type I and Type II Topoisomerases.

druga gyrase Topo IV hTopo II hTopo I
az4.9 90% 95% 95% >95%
kb6.4 85% 80% >95% 60%
kz6 75%     >95%
kp5.8 b     70%
na1–6        
nz5.6 >95%   >95% >95%
np5.9 95% >95% >95% >95%
a

Compounds screened at 200 μM.

b

Blank spaces: <5% inhibition.