Table 2. Inhibition of Ciprofloxacin-Induced DNA Cleavagea.
compound | Ec gyrase | Sa gyrase | Ec Topo IV |
---|---|---|---|
az4.9 | - | - | + |
kb6.4 | - | - | + |
kz6 | + | + | + |
kp5.8 | ND | ND | - |
nz5.6 | + | + | + |
np5.9 | - | - | + |
ND: not determined; + indicates greater than 95% inhibition.