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Variation of predicted annotation quality with phylogenetic distance to model organism. Left: Scatter-plot showing predicted annotation quality (precision of annotated reactions according to the classifier) for eukaryotes against phylogenetic distance to H.sapiens. Right: Scatter plot showing predicted annotation quality for prokaryotes against phylogenetic distance to E.coli (Ciccarelli et al., 2006). The shaded region shows the 95% confidence interval for the regression line
