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. 2013 Apr 24;33(17):7439–7450. doi: 10.1523/JNEUROSCI.4506-12.2013

Figure 9.

Figure 9.

A, Immunohistochemical profile of hippocampal astrocytes in GFAPTg;Gfap+/R236H (Tg/KI), Gfap+/R236H(KI), GFAPTg (Tg), and WT mice at 4 weeks of age. Note that in GFAPTg;Gfap+/R236H mice, astrocytes with reactive-like phenotype occupy most of the CA1 str.rad., whereas in Gfap+/R236H and Tg they are located mainly in str.lac-mol. Pathology in the Gfap+/R236H GFAPT mice is more severe than in WT, but not as severe as the GFAPTg;Gfap+/R236H. Confocal microscopy; scale bars, 185 μm. B, Quantitation of the number of nestin+ and p-S6+ reactive astrocytes in the CA1 str.rad. in the three AxD lines at 4 weeks. The number of reactive astrocytes in GFAPTg;Gfap+/R236H is significantly higher than in GFAPTg and Gfap+/R236H. One-way ANOVA with Tukey's test, p < 0.001. The WT hippocampus did not show any nestin+ or p-S6+ astrocytes (data not shown and not included in statistical analysis).