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. Author manuscript; available in PMC: 2014 Feb 28.
Published in final edited form as: J Phys Chem C Nanomater Interfaces. 2013 Feb 8;117(8):4268–4277. doi: 10.1021/jp312031u

Scheme 1.

Scheme 1

Schematic diagram of the cleavage of Fc-linked tetrapeptides at the VACNF NEA tip by specific proteases. (a) A random VACNF array embedded in the SiO2 matrix. (b) Electron transfer from appended ferrocene at the distal end of the peptide to the underlying metal film electrode through the VACNFs and the loss of the electrochemical signal from ferrocene due to the cleavage of the peptide at specific sites.