Scheme 1.
Schematic diagram of the cleavage of Fc-linked tetrapeptides at the VACNF NEA tip by specific proteases. (a) A random VACNF array embedded in the SiO2 matrix. (b) Electron transfer from appended ferrocene at the distal end of the peptide to the underlying metal film electrode through the VACNFs and the loss of the electrochemical signal from ferrocene due to the cleavage of the peptide at specific sites.