Figure 5. Transplant experiments in the Krox20Cre tumor model.

The left column shows the genetic status of Schwann cells, vascular cells, fibroblasts, and marrow cells in two different mice genotypes: the Nf1^flox/-Krox20Cre tumor model and the Nf1^flox/floxKrox20Cre model, which does not develop tumors. The arrows indicate the genotype of the hematopoietic stem cells transplanted into these two different genotypes of mice. “W” represents either W⁴¹ or W^v c-kit receptor tyrosine kinase deficient mutations. The right column and bottom box show the resultant genetic status of each cell lineage, post-transplant. As indicated, only those mice with Nf1^-/- Schwann cells and c-kit-competent Nf1^+/- bone marrow develop tumors. HSCT: hematopoietic stem cell transplant.