TABLE 1.
Estimated peak titers of viruses with HA and NA combinations rescued on different vaccine backbones in Vero cells
| Source of HA and NA | Backbone | Estimated peak titera | 95% Confidence interval | P value |
|---|---|---|---|---|
| PR8 | PR8/Eng-NS | 16.59 | 16.15-17.03 | 0.4854 |
| PR8 | 16.33 | 15.76-16.90 | ||
| A/New Caledonia/20/99 | PR8/Eng-NS | 16.87 | 16.44-17.30 | 0.0041b |
| PR8 | 15.81 | 15.27-16.34 | ||
| A/Panama/2007/99 | PR8/Eng-NS | 16.48 | 15.99-16.96 | 0.0001b |
| PR8 | 14.90 | 14.34-15.46 | ||
| A/quail/Hong Kong/G1/97 | PR8/Eng-NS | 16.29 | 15.88-16.70 | 0.2589 |
| PR8 | 15.87 | 15.28-16.46 | ||
| A/teal/Hong Kong/W312/97 | PR8/Eng-NS | 13.66 | 13.18-14.14 | 0.0011b |
| PR8 | 12.18 | 11.59-12.78 |
a
Expressed as natural log of number of PFU per milliliter.
b
Indicates subtypes for which the peak titer of the PR8/Eng-NS variant was statistically higher than that of the PR8 variant.