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. Author manuscript; available in PMC: 2013 Jun 27.
Published in final edited form as: Prog Nucleic Acid Res Mol Biol. 2008;82:101–145. doi: 10.1016/S0079-6603(08)00004-4

Figure 4. Nascent Base Pair Binding Pocket of A B Family Polymerase.

Figure 4

Surface representation of the nascent base pair and several amino acids in RB69 Pol that form the DNA minor groove edge of the binding pocket at the polymerase active site (Adapted from (212) with the author’s permission). Met644 in yeast Pol ε (in parentheses) aligns with Leu415 in RB69 Pol (green). The adjacent Tyr416 in RB69 Pol aligns with Tyr869 in yeast Pol α, which, when substituted with alanine, results in a mutator phenotype.