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. Author manuscript; available in PMC: 2013 Jun 27.
Published in final edited form as: Prog Nucleic Acid Res Mol Biol. 2008;82:101–145. doi: 10.1016/S0079-6603(08)00004-4

Figure 5. Model of A Eukaryotic Replication Fork.

Figure 5

This model is based on the currently favored hypothesis that Pol ε is primarily responsible for leading strand synthesis, shown in blue, and Pol δ is primarily responsible for lagging strand synthesis, shown in green. Pol α-primase cooperates with Pol δ to conduct lagging strand synthesis, with the initiating RNA primers shown in red. RPA heterotrimers are shown in violet. The CMG replicative helicase is shown as a heterohexameric MCM complex (orange) associated with the GINS complex (green) and Cdc45 (light red).