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. 2013 Jul 1;24(13):2076–2087. doi: 10.1091/mbc.E13-01-0010

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© 2013 Shiber et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Ssa1 and Ssa2 are essential for the degradation of proteins containing the degron domain of Ndc10. (A) Degradation of Ndc10-2 requires either of the Hsp70 chaperones Ssa1 or Ssa2 (Ssa1/2). (B) Schematic presentation of the topology of substrates used in this study. Top, fusion between GFP and the 100-aa Ndc10 degron (DegAB). Bottom, fusion between the ER-anchored protein Vma12 and DegAB. (C, D) Degradation of Vma12-DegAB and GFP- DegAB, respectively, requires intact Ssa1/2.