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. Author manuscript; available in PMC: 2014 Jun 14.
Published in final edited form as: Biochem Biophys Res Commun. 2013 May 9;435(4):551–556. doi: 10.1016/j.bbrc.2013.04.100

Figure 2.

Figure 2

The bHLHZ of N-Myc is Necessary for Direct Interaction with Utf1.

(A) Schematic diagram outlining the conserved domains of the N-Myc protein as well as N-Myc truncation proteins generated for pull down. The following bars summarize the pull down results. I = Myc Box I, II = Myc Box II, III = Myc Box III, B = Basic Region, HLH = Helix-loop-helix, Z = Leucine zipper domain, Red bar = negative pull down interaction, Green bar = positive pull down interaction.

(B) Pull down results showing positive interaction of N-Myc 260-462 AA and N-Myc-360-462 AA with both isoforms of Utf1.

(C) Pull down results after treating N-Myc 260-460 AA with DNase I.