Table 3. Comparison of four rapid diagnostic tests on randomly-selected serum samples.
MAT | Pasteur RDT 1/400 | Leptocheck | Elisa Serion (+RF absorbant) | Elisa Panbio |
Positive 72 | Positive 59 | Positive 59 | Positive 58 | Positive 53 |
Negative 5 | ||||
Negative 1 | Positive 0 | |||
Negative 1 | ||||
Negative 0 | Positive 0 | Positive 0 | ||
Negative 0 | ||||
Negative 0 | Positive 0 | |||
Negative 0 | ||||
Negative 13 | Positive 11 | Positive 8 | Positive 1 | |
Negative 7 | ||||
Negative 3 | Positive 0 | |||
Negative 3 | ||||
Negative 2 | Positive 0 | Positive 0 | ||
Negative 0 | ||||
Negative 2 | Positive 0 | |||
Negative 2 | ||||
Sensitivity | 81.9% [71.5–89.1] | 97.2% [90.4–99.2] | 91.7% [83–86.1] | 75% [63.9–83.6] |
Negative 72 | Negative 69 | Negative 38 | Negative 59 | Negative 72 |
Specificity | 95.8% [88.4–98.6] | 52.8% [41.4–63.9] | 81.9% [71.5–89.1] | 100% [94.9–100] |
LR+ * | 19.7 [6.5–59.9] | 2.1 [1.6–2.6] | 5.1 [3.1–8.3] | NA |
LR− † | 0.2 [0.1–0.3] | 0.05 [0.01–0.21] | 0.1 [0.05–0.2] | 0.25 [0.17–0.37] |
DOR ‡ | 104.4 [28.4–384] | 39.1 [8.9–171.8] | 49.9 [17.8–139.7] | NA |
NA: Not Applicable.
LR+: Positive Likelihood Ratio – [95% CI].
LR−: Negative Likelihood Ratio – [95% CI].
DOR: Diagnostic Odds Ratio – [95% CI].
Sensitivity (%), number of positive rapid diagnostic test among patients with serological evidence (MAT) of leptospirosis (n = 72) – [95% CI].
Specificity (%), negative rapid diagnostic test among serum samples from patients with no serological evidence (MAT) of leptospirosis (n = 72) – [95% CI].