Figure 7. Acute treatments with Fasudil or PD98059 attenuate the enhanced responsiveness of the diabetic mesenteric vascular bed to norephinephrine.

The responsiveness of the isolated perfused mesenteric vascular bed from non-diabetic control and diabetic animals to stated doses of Norephinephrine (NE) are shown following acute treatment with Fasudil (10⁻⁶ M; D+FAS) or PD98059 (10⁻⁶ M; D+PD). Mean+S.D; N = 6; Mean values were compared using analysis of variance followed by post hoc test (Bonferroni). (* Significantly different from control, # significantly different form diabetes).