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. 2013 Jun 27;8(6):e67813. doi: 10.1371/journal.pone.0067813

Figure 9. High glucose-induced changes in ROCKs and ERK1/2 can be blocked by AG1478, a selective inhibitor of EGFR, in VSMC.

Figure 9

Panel a) is a representative Western blot showing total (t-) or phosphorylated (p) levels of the stated proteins in VSMC grown in normal (5.5mM) D-glucose (NG), high glucose (25.5mM D-glucose; HG) or HG cotreated with AG1478 (+ AG1478). Panels b-h) are densitometry histograms showing total (t-) or phosphorylated (p-) levels of the stated proteins normalized to actin. N = 5; Mean±SD. Asterisk (*) indicates significantly different (p<0.05) mean values from normal non-diabetic rats (C) whereas hash (#) indicates significantly different mean values (p<0.05) from diabetic rats (D).