Table 2. Overall and age-specific incidence densities and relative hazards of breast cancer (ICD-9∶174) in the diabetes and control groups.
Control Group | Diabetes Group | Crude HR (95% CI) in association with diabetes group | Adjusted HR† (95% CI) in association with diabetes group | |||||
No. of subjects | No. of events | ID* (per 10,000 patient-years) (95% CI) | No. of subjects | No. of events | ID* (per 10,000 patient-years) (95% CI) | |||
Age (years) | ||||||||
20–49 | 55602 | 562 | 1.15(1.06–1.25) | 55601 | 536 | 1.14(1.05–1.24) | 0.99(0.88–1.12) | 1.16(1.02–1.31) |
50–64 | 128389 | 1311 | 1.17(1.11–1.24) | 128389 | 1432 | 1.37(1.30–1.44) | 1.17(1.09–1.26) | 1.40(1.29–1.51) |
≧65 | 135317 | 783 | 0.74(0.69–0.80) | 135318 | 977 | 1.05(0.99–1.12) | 1.41(1.28–1.55) | 1.61(1.45–1.78) |
Total | 319308 | 2656 | 1.00(0.96–1.04) | 319310 | 2945 | 1.21(1.16–1.25) | 1.21(1.15–1.28) | 1.42(1.34–1.50) |
ID, incidence density; CI, confidence interval; HR, hazard ratio; AHR, adjusted hazard ratio.
Based on Poisson assumption.
Based on Cox proportional hazard regression with adjustment for age, geographic area, urbanization status, Charlson’s score, history of hypertension, endometriosis, and abortion, and frequency of medical visit.