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. 2013 Jun 27;8(6):e67420. doi: 10.1371/journal.pone.0067420

Table 2. Overall and age-specific incidence densities and relative hazards of breast cancer (ICD-9∶174) in the diabetes and control groups.

Control Group Diabetes Group Crude HR (95% CI) in association with diabetes group Adjusted HR (95% CI) in association with diabetes group
No. of subjects No. of events ID* (per 10,000 patient-years) (95% CI) No. of subjects No. of events ID* (per 10,000 patient-years) (95% CI)
Age (years)
20–49 55602 562 1.15(1.06–1.25) 55601 536 1.14(1.05–1.24) 0.99(0.88–1.12) 1.16(1.02–1.31)
50–64 128389 1311 1.17(1.11–1.24) 128389 1432 1.37(1.30–1.44) 1.17(1.09–1.26) 1.40(1.29–1.51)
≧65 135317 783 0.74(0.69–0.80) 135318 977 1.05(0.99–1.12) 1.41(1.28–1.55) 1.61(1.45–1.78)
Total 319308 2656 1.00(0.96–1.04) 319310 2945 1.21(1.16–1.25) 1.21(1.15–1.28) 1.42(1.34–1.50)

ID, incidence density; CI, confidence interval; HR, hazard ratio; AHR, adjusted hazard ratio.

*

Based on Poisson assumption.

Based on Cox proportional hazard regression with adjustment for age, geographic area, urbanization status, Charlson’s score, history of hypertension, endometriosis, and abortion, and frequency of medical visit.