Table 3. Clinical characteristics of patients with viral resistance.
Patient | Ethnicity | HBeAg status | HBV-genotype | Treatment regimen | Duration of minimal residual viremia until viral resistance (months) | Serum samples with minimal residual viremia (n) | Viral mutation | HBV-DNA (IU/mL) at time of resistance |
Patient 1 | Caucasian | Negative | D | ADV | 45 | 7/7 | A181V, | 81200 |
(100%) | N236X | |||||||
Patient 2 | Caucasian | Positive | A | ADV | 21 | 4/4 | N236T | 71600 |
(100%) | ||||||||
Patient 3 | Caucasian | Negative | A | LAM | 31 | 5/5 | M204I | 4240 |
(100%) |