Table 4. Multivariate analysis of the prognostic factors for patients with pT4 gastric cancers.

Variable	Chi-Square	P value	HR	95% CI
Multivariate model with AJCC pT4 subclassification
Tumor size	3.8287	0.0504	1.301	1–1.693
Resection type	1.748	0.1861	1.169	0.927–1.474
Longitudinal location
Lower
Middle	1.1906	0.2752	0.811	0.557–1.181
Upper	0.0036	0.9522	0.989	0.688–1.422
Entire	0.5089	0.4756	0.902	0.679–1.198
Circumferential location	0.3364	0.5619	1.082	0.829–1.413
Histologic type	3.4563	0.063	1.195	0.99–1.442
Lymphatic/Venous invasion	1.644	0.1998	1.15	0.929–1.424
Lymph node metastasis *
pN0
pN1	9.8314	0.0017	1.852	1.26–2.722
pN2	53.3023	<.0001	3.536	2.519–4.964
pN3	91.1172	<.0001	5.018	3.603–6.988
Chemotherapy *	16.461	<.0001	0.675	0.558–0.816
AJCC pT4 subclassification *	44.7389	<.0001	1.994	1.629–2.441
Multivariate model with Novel pT4 subclassification
Tumor size	0.2576	0.6118	1.07	0.823–1.391
Resection type	1.3143	0.2516	1.141	0.911–1.428
Longitudinal location
Lower
Middle	1.0346	0.3091	0.825	0.57–1.195
Upper	0.0274	0.8686	0.971	0.682–1.381
Entire	0.1503	0.6983	0.947	0.718–1.249
Circumferential location	0.6853	0.4078	0.893	0.683–1.168
Histologic type	3.6738	0.0553	1.2	0.996–1.447
Lymphatic/Venous invasion	3.5119	0.0609	1.22	0.991–1.501
Lymph node metastasis *
pN0
pN1	10.7941	0.001	1.906	1.297–2.801
pN2	51.3088	<.0001	3.459	2.463–4.858
pN3	80.7698	<.0001	4.602	3.299–6.419
Chemotherapy *	17.2113	<.0001	0.67	0.554–0.809
Novel pT4 subclassification *	51.4444	<.0001	2.066	1.694–2.519

^*Statistically significant (P<0.05).