Figure 7. Cyanide abolishes the inhibitory effect of the respiratory chain substrates succinate and NADH.

A. Single-channel recordings of the mitoBK_Ca channel activity in symmetric 150/150 mM KCl isotonic solution (200 µM Ca²⁺) at +40 mV under control conditions, after the addition of 30 µM KCN and 5 mM succinate plus 30 µM KCN, and after perfusion. B. Single-channel recordings of the mitoBK_Ca channel activity in symmetric 150/150 mM KCl isotonic solution (200 µM Ca²⁺) at +40 mV under control conditions, after the addition of 30 µM KCN and 200 µM NADH plus 30 µM KCN, and after perfusion. C. Distribution of P_o at different voltages under the conditions described in A and B.