Table 5. Multivariate analysis of prognostic markers in 263 patients with colon cancer.
| Variable | Adjusted HR (95% CI)* , # | P * |
| Depth of invasion | 0.572 (0.225–1.456) | 0.241 |
| T1+ T2 (n = 33) | ||
| T3+ T4 (n = 230) | ||
| Nodal status | 0.476 (0.204–1.111) | 0.086 |
| N0 (n = 126) | ||
| N1+ N2+ N3 (n = 137) | ||
| Distant metastasis | 0.052 (0.024–0.111) | <0.001 |
| Absent (n = 224) | ||
| Present (n = 39) | ||
| Stage | 1.375 (0.485–3.895) | 0.549 |
| I+II (n = 116) | ||
| III+IV (n = 147) | ||
| Degree of differentiation | 0.000 (0.000–253E250) | 0.970 |
| Poor (n = 16) | ||
| Well to moderate (n = 247) | ||
| Vascular invasion | 0.673 (0.385–1.177) | 0.165 |
| Absent (n = 124) | ||
| Present (n = 139) | ||
| Perineural invasion | 1.074 (0.646–1.786) | 0.782 |
| Absent (n = 206) | ||
| Present (n = 57) | ||
| Nuclear SOX4 | 0.829 (0.522–1.315) | 0.425 |
| Low expression (n = 144) | ||
| High expression (n = 119) |
*
All statistical tests were two-tailed and the significance level was P<0.05.
#
Adjusted HR was obtained by depth of invasion, nodal status, distant metastasis, stage, degree of differentiation, vascular invasion, perineural invasion, and nuclear SOX4 expression.