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. 2013 Jun 27;8(6):e67134. doi: 10.1371/journal.pone.0067134

Figure 10. Pathway diagram of the KEGG Jak-Stat pathway using DAVID analysis.

Figure 10

EVI1 binds to the majority (78%) of major genes involved in the regulation of the Jak-Stat signaling pathway. These include Il10, Il10ra, Il6, Il6ra, Cbl, Jak1, Pias2, Stat1, Stat4, Stat5, Stat6, Grb, Sos2, Akt1, Akt2, Socs1,Pim1, Ccnd1, Ccnd2, Ccnd3, Myc, and Spred1. EVI1 binds to an AGGAAG ETS-like motif which is present in the promoter region of all of these Jak-Stat pathway genes. Illustration taken from DAVID website http://david.abcc.ncifcrf.gov/.