Table 5. Model statistics of Cox regression for all baseline scores (adjusted for age, gender, and education).

	Continuous predictors					Categorical predictors (median split)
	Overall model		Continuous values			Overall model		Values below vs. above median
	χ2	p	Hazard rate[CI]	Wald statistics	p	χ2	p	Hazard ratio [CI]	Wald statistics	p
BrainAGE score (+)	58.86	***	1.10	45.05	***	52.23	***	3.41	37.03	***
			[1.07–1.13]					[2.30–5.07]
MMSE score (-)	28.99	***	0.81	16.01	***	25.04	***	2.02	12.55	***
			[0.73–0.90]					[1.37–2.99]
CDR-SB score (+)	30.46	***	1.15	19.41	***	26.74	***	1.97	13.89	***
			[1.26–1.82]					[1.38–2.82]
ADAS score (+)	56.02	***	1.11	40.48	***	29.78	***	2.12	16.84	***
			[1.07–1.14]					[1.48–3.03]
Left hippocampus volume (-)	34.54	***	1.00	21.82	***	23.84	***	1.91	11.34	**
			[1.00–1.00]					[1.31–2.78]
Right hippocampus volume (-)	31.65	***	1.00	18.90	***	18.56	**	1.59	6.32	*
			[1–00–1.00]					[1.11–2.28]

(+) = higher values mean higher risk for AD; (-) = lower values mean higher risk for AD.

^***p<0.001;

^**p<0.01;

^*p<0.05; n.s. = not significant.

Bold type = best performance of all markers.