Table 7.
CNV Training Set Model 4: Full Model-Simplified Severity Scale plus Genetics plus Environment (Brier Score=0.100)
| Variable | Hazard Ratio | ln (SE) | 95% Confidence Interval |
p-value |
|---|---|---|---|---|
| Simplified Severity Scale 1 | 4.76 | 0.34 | 2.43, 9.34 | 5.61E-06 |
| Simplified Severity Scale 2 | 12.66 | 0.31 | 6.87, 23.36 | 4.44E-16 |
| Simplified Severity Scale 3 | 26.56 | 0.31 | 14.53, 48.58 | <2.00E-16 |
| Simplified Severity Scale 4 | 35.89 | 0.30 | 19.75, 65.21 | <2.00E-16 |
| SNP rs1061170 | 0.75 | 0.13 | 0.58, 0.97 | 0.0294 |
| SNP rs2274700 | 0.77 | 0.16 | 0.56, 1.06 | 0.1052 |
| SNP rs12144939 | 0.73 | 0.21 | 0.48, 1.11 | 0.1401 |
| SNP rs1409153 | 1.55 | 0.15 | 1.15, 2.09 | 0.0045 |
| SNP rs1750311 | 1.50 | 0.24 | 0.93, 2.43 | 0.0958 |
| SNP rs10922153 | 0.63 | 0.29 | 0.36, 1.11 | 0.1119 |
| SNP rs698859 | 0.67 | 0.21 | 0.44, 1.01 | 0.0554 |
| SNP rs2990510 | 0.66 | 0.23 | 0.42, 1.04 | 0.0705 |
| SNP rs10490924 | 1.46 | 0.07 | 1.27, 1.67 | 1.43E-07 |
| SNP rs2230199 | 1.12 | 0.08 | 0.96, 1.31 | 0.1362 |
| SNP rs9332739 | 0.57 | 0.26 | 0.34, 0.96 | 0.0351 |
| SNP rs641153 | 0.65 | 0.18 | 0.46, 0.93 | 0.0169 |
| Previous Smoker (6 Months) | 1.24 | 0.11 | 1.01, 1.52 | 0.0438 |
| Current Smoker | 1.78 | 0.21 | 1.18, 2.67 | 0.0056 |
| Age | 1.05 | 0.01 | 1.03, 1.07 | 5.81E-06 |
CNV = choroidal neovascularization; ln (SE) = natural log of the standard error; SNP = single nucleotide polymorphism