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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Nat Genet. 2013 May 19;45(7):756–766. doi: 10.1038/ng.2641

Figure 1. SB mutagenesis induced and accelerated grade 3 PNST formation.

Figure 1

(a) Bar graph depicting the percentage of mice that developed each tumor type at the time of necropsy based on genotype. p-values reflect FET. (b) Survival curve depicting incidence of grade 3 tumor formation in Trp53R270H; Cnp-EGFR control mice compared to mice undergoing transposition with Trp53R270H; Cnp-EGFR background. Median age of tumor-free survival was 313 days (n=87) with transposition compared to 443 days (n=29) in the control. Log rank test: p<0.0001.

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