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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Nat Neurosci. 2013 Jun 2;16(7):903–909. doi: 10.1038/nn.3415

Figure 4. Higher probability of neuronal firing during Up states in Fmr1–/– mice.

Figure 4

(a) Sample traces during Up/Down states from in vivo whole cell recordings of L2/3 neurons in unanesthetized WT (top) and Fmr1–/– mice (bottom). The highlighted segments are expanded in panel b.

(b) Expanded traces of Up & Down segments in WT (top) and Fmr1–/– mice (bottom).

(c, d) Mean duration (c) and frequency (d) of Up states in WT and Fmr1–/– mice. Note that not all recordings (or neurons) showed segments that were classified as Up/Down states (n = 5 and 6 recording segments with Up/Down states in WT and Fmr1–/– mice, respectively). There were no significant differences between genotypes.

(e) Mean Up-Down voltage step (in mV) in WT and Fmr1–/– mice. The trend toward higher step in mutant mice was not significant (p = 0.21, t-test).

(f) Mean number of action potentials per active Up state (i.e., Up states with 1 or more spikes) in WT and Fmr1–/– mice. p = 0.07, t-test.

(g) Mean firing probability during any given Up state (active or silent) in WT and Fmr1–/– mice. **p < 0.01, t-test.