Table 2.

Genetic polymorphism studies involved in stroke related to homocysteine metabolism pathway

S. no.	Gene	Mutation	Significance in stroke	Odds ratio (95 % CI)	Reference
1	MTHFR (1p36.3)	677 C→T	Associated with increased Hcy levels and stroke risk	1.26 (1.14–1.40)	[10, 15, 22]
2	CBS (21q22.3)	833 C→T 919G→A	C833T associated with higher plasma Hcy levels and correlated with stroke	1.57 (1.02–2.41)	[9, 11]
3	MS (1q43)	2,756 A→G	Associated with HHcy and risk factor for thromboembolic events	1.58	[24]
4	MTRR (5p15.31)	rs16879248 (T/C)	Associated with Hcy metabolism and ischemia stroke risk	0.75 (0.61–0.91)	[14]
5	SHMT1 (17p11)	rs11868708 (T/C)	Associated with Hcy metabolism and ischemia stroke risk	1.24 (1.05–1.46)	[14]
6	TCN2 (22q12)	rs11703570 (C/T)	Associated with Hcy metabolism and ischemia stroke risk	1.28 (1.04–1.57)	[14]
7	NNMT (11q23)	rs694539 (A/G)	Influences plasma Hcy levels: the GAIT project	–	[17]