Skip to main content
. 2013 Jun 27;8(6):e67204. doi: 10.1371/journal.pone.0067204

Figure 8. IGF-1 expression reduced post-traumatic behavioral impairment after severe brain injury.

Figure 8

A) In the modified neurological severity score (NSS), a test series of beam walking tasks, IGF-1 overexpressing (IGF-1Tg) mice exhibited significantly better coordinated motor function compared to wildtype (WT) mice over the first 4d after severe (1.0 mm) CCI. B) In the novel object recognition (NOR) does task, the recognition index represent the percent exploration time spent on the novel object. IGF-1 overexpression prevented posttraumatic memory impairment at 7d post-injury. Data expressed as mean+SEM. * p<0.05 comparing WT CCI and WT sham, # p<0.05 comparing IGF-1 Tg CCI and IGF-1Tg sham, and ! p<0.05 comparing IGF-1Tg CCI to WT CCI.