Table 2.
Genes implicated in hereditary ovarian carcinoma
FA-BRCA pathway genes | HBOC |
BRCA1 | |
BRCA2 | |
RAD51C | Low penetrance genes |
RAD51D | |
BRP1 | |
BARD1 | |
CHEK2 | |
MRE1 1A | |
NBN | |
PALB2 | |
RAD50 | |
Mismatch repair genes | Lynch syndrome |
MLH1 | |
MSH2 | |
MSH6 | |
PMS2 | |
Other genes | Li–Fraumeni syndrome |
TP53 |
HBOC hereditary breast and ovarian cancer