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Mutations in BRCA1/2 genes and mismatch repair genes in HBOC and Lynch syndrome
| HBOC | Lynch syndrome | |
|---|---|---|
| Genes | BRCA1 and BRCA2 | MLH1, MSH2, MSH6 and PMS2 |
| Increased risk of cancer | Breast, ovarian, pancreatic, prostate | Colon, uterine, ovarian, other cancers of the digestive tract |
HBOC hereditary breast and ovarian cancer
