Figure 1.

Schematic representation of the downstream targets of oncogenic signaling pathways that affect mitotic fidelity. The inner circle represents chromosomal instability (CIN) and the middle circle is composed of the four primary defects in mitosis known to cause CIN. The downstream targets of oncogenic pathways involved in the four primary CIN-causing mitotic defects comprise the outer circle. Note that some downstream targets (e.g., APC) have been demonstrated to play a role in more than one CIN-causing mitotic defect.