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Proposed mechanism. Stimulation of either EphB4 receptor by EphrinB2 or EphrinB2 by EphB4 results in increased Erk phosphorylation (circled P) that leads to increased KLF2 and VEGF promoter activity. HSC-derived VEGF, in turn, provides a chemotactic stimulus for SEC migration and recruitment. In an in vivo setting EphrinB2/EphB4 stimulation may occur by cell to cell contact between HSC or between HSC and SEC.
