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. Author manuscript; available in PMC: 2013 Jun 28.
Published in final edited form as: J Child Neurol. 2010 Jun 2;25(9):1165–1170. doi: 10.1177/0883073810371130

Figure 2.

Figure 2

A. The mdx mouse model of Duchenne muscular dystrophy is attributable to a nonsense mutation in exon 23 that blocks translation beyond this point

B. Because exon 23 is not a frame-shifting exon, it can be skipped to generate a translatable transcript that produces dystrophin.