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. Author manuscript; available in PMC: 2013 Aug 3.
Published in final edited form as: Circ Res. 2012 Jun 22;111(4):469–481. doi: 10.1161/CIRCRESAHA.112.266361

Figure 1. Enhancement of extracellular Ca2+-induced increase in [Ca2+]cyt in PASMC from IPAH patients.

Figure 1

A-C. Representative records (A), pseudo-color images (B), and summarized data (means±SE, C) showing extracellular Ca2+-mediated changes in [Ca2+]cyt in PASMC from normal subjects (n=45 cells), IPAH patients (n=160 cells), and CTEPH patients (n=27 cells). Two kinetically different responses of [Ca2+]cyt to extracellular Ca2+ in PASMC from two IPAH patients are shown in the middle panels. D. Representative traces of [Ca2+]cyt changes in response to extracellular application of 0.1, 0.5, 1.1, 2.2, and 10 mM Ca2+ (left panels) and the dose-response curves (right panel) in normal PASMC (upper panel) and IPAH-PASMC (lower panel). The EC50 for extracellular Ca2+-induced [Ca2+]cyt increase in IPAH-PASMC is 1.22 mM.