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. 2013 Apr 27;41(12):6045–6057. doi: 10.1093/nar/gkt324

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Transcriptional regulatory region of PvuII RM system. (A) Genetic map of PvuII system. The three genes pvuIIM, pvuIIC and pvuIIR code, respectively, for the MTase, activator–repressor and endonuclease. Bent arrows followed by wavy lines indicate promoters and their mRNAs. (B) Sequence of the regulatory region. The sites of C.PvuII activation/repression, the initiation codons for pvuIIM and pvuIIC, and the transcript 5′ ends, are from experimental data (see text for references); the locations of the −10 and −35 hexamers are inferred from the transcript starting points. P_CR1 is a very weak promoter, repressed by C.PvuII, that is believed to initiate the autogenous activation cycle by providing a low initial amount of pvuIIC transcription; P_CR2 is the much stronger promoter that is controlled by C.PvuII. P_M1 and P_M2 are responsible for transcription of pvuIIM.