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. 2013 Apr 30;41(12):e126. doi: 10.1093/nar/gkt344

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© The Author(s) 2013. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Determination of siRNA in the blood of mice after intravenous administration. (A) ¹⁸O/¹⁶O isotope ratio as a function of ¹⁸O-labeled control siRNA concentration. δ¹⁸O values were calculated from the results of IRMS, and the concentration of ¹⁸O-labeled control siRNA in the plasma was determined by its absorbance at 260 nm. Each value is the average of at least three independent experiments. (B) Blood concentration-time curve of control siRNA. The RNA concentrations were calculated from the δ¹⁸O values of the plasma samples. Each value is the average of at least three independent experiments.