Table 1. Average of structural chromosomal abnormalities observed in bone marrow cells of male rats treated with amiodarone and grapefruit juice (mean±SE).

Animal group	Deletion	Chromatid fragment	Centromeric attenuation	End to end association	Centric fusion	Chromosomal ring	Gaps	Breaks	Total
Normal	10.00±0.44	4.20±0.37	0.60±0.24	0.60±0.24	0.00±0.00	16.00±0.70	0.00±0.00	0.00±0.00	31.40±1.99
Grapefruit juice	9.60±2.27	16.00±1.12	0.00±0.00	1.20±0.49	1.20±0.97	16.20±3.30	0.60±0.24	0.00±0.00	44.80±8.39
Amiodarone	36.60±3.80	16.00±1.18	2.40±0.74	1.80±0.73	2.60±0.67	30.80±2.47	2.80±0.37	1.60±0.40	94.60±10.36*
Amiodarone+grape- fruit juice	17.00±2.55	13.80±1.62	1.40±0.24	1.40±0.40	2.40±0.24	11.00±1.00	0.00±0.00	0.20±0.20	47.20±6.25

*Significant at P<0.05.