Table 3. Mean value of DNA damage detected by comet assay in rat lymphocytes treated with amiodarone and grapefruit juice (mean±SE).
Animal group | Normal cells | Damaged cells | Strongly damaged cells | Total damaged cells |
Control | 97±0.83 | 3±0.83 | 0±0.00 | 3±0.83 |
Grapefruit juice | 95±1.09 | 5±1.09 | 0±0.00 | 5±1.09* |
Amiodarone | 80±2.32*# | 18±1.64*# | 2±0.70# | 20±2.32*# |
Amiodarone+grapefruit juice | 89±1.34*#° | 10±0.83*#° | 1±0.54 | 11±1.34*#° |
*Statistically significant in comparison with control; #Statistically significant in comparison with grapefruit; °Statistically significant in comparison with treatement with cordarone.