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. 2013 Jul;3(7):573–579. doi: 10.1016/S2221-1691(13)60116-1

Table 3. Mean value of DNA damage detected by comet assay in rat lymphocytes treated with amiodarone and grapefruit juice (mean±SE).

Animal group Normal cells Damaged cells Strongly damaged cells Total damaged cells
Control 97±0.83 3±0.83 0±0.00 3±0.83
Grapefruit juice 95±1.09 5±1.09 0±0.00 5±1.09*
Amiodarone 80±2.32*# 18±1.64*# 2±0.70# 20±2.32*#
Amiodarone+grapefruit juice 89±1.34*#° 10±0.83*#° 1±0.54 11±1.34*#°

*Statistically significant in comparison with control; #Statistically significant in comparison with grapefruit; °Statistically significant in comparison with treatement with cordarone.