Table 2.

Result of the gout-associated ALPK1 SNPs

		Cases				Controls
SNP	R/NR	11	12	22	1	11	12	22	1	HWE P	P (trend)	OR (95% CI)	Adjusted OR (95% CI)a
Taiwan aborigines
rs9994944	G/A	229	221	61	0.66	324	392	124	0.62	0.76	1.87 × 10−2	1.21 (1.03–1.43)	1.26(1.05–1.52)
rs2074388 G565D	A/G	180	243	88	0.59	214	414	212	0.50	0.68	9.03 × 10−6	1.43 (1.22–1.67)	1.41(1.18–1.69)
rs13148353 H642R	G/A	191	240	80	0.61	244	404	192	0.53	0.32	1.04 × 10−5	1.36 (1.17–1.59)	1.39(1.16–1.66)
rs2074379 M732I	A/G	184	246	81	0.60	237	405	198	0.52	0.33	1.03 × 10−4	1.36 (1.17–1.59)	1.37(1.14–1.63)
rs11726117 M861T	C/T	198	237	76	0.62	244	396	200	0.53	0.11	3.78 × 10−6	1.44 (1.23–1.69)	1.45(1.21–1.73)
rs231247 R1084R	G/A	195	233	83	0.61	225	414	201	0.51	0.70	2.00 × 10−6	1.46 (1.25–1.71)	1.48(1.24–1.77)
rs55840220 T1145T	A/G	23	131	357	0.17	21	125	694	0.10	<0.01	1.89 × 10−7	1.76 (1.42–2.18)	1.71 (1.33–2.18)
rs231253, 3' UTR	G/C	190	239	82	0.61	223	416	201	0.51	0.80	3.48 × 10−6	1.45 (1.24–1.70)	1.43(1.20–1.71)
rs960583, 3' UTR	A/G	25	159	327	0.20	19	224	597	0.16	0.71	1.37 × 10−3	1.39 (1.13–1.69)	1.33(1.06–1.66)
Taiwanese Han
rs11726117 M861T	C/T	70	31	3	0.82	209	168	30	0.72	0.64	2.50 × 10−3	1.82 (1.23–2.70)	2.41 (1.41–4.12)
rs231247 R1084R	G/A	70	28	6	0.81	204	167	36	0.71	0.83	4.08 × 10−3	1.72 (1.18–2.50)	2.15 (1.31–3.50)
rs231253, 3' UTR	G/C	63	35	6	0.77	215	164	28	0.73	0.66	1.92 × 10−1	1.27 (0.89–1.83)	1.36 (0.84–2.20)
Pooled analysisb
rs11726117 M861T	C/T	268	268	79	0.65	453	564	230	0.59		2.89 × 10−8	1.51 (1.31–1.75)	1.53 (1.30–1.81)
rs231247 R1084R	G/A	265	261	89	0.64	429	581	237	0.58		2.05 × 10−8	1.52 (1.31–1.75)	1.55 (1.31–1.83)
rs231253, 3' UTR	G/C	253	274	88	0.63	438	580	229	0.58		1.53 × 10−6	1.42 (1.23–1.65)	1.42 (1.21–1.68)

R, risk allele; NR, non-risk allele; 11 indicates at-risk homozygote, 12 indicates heterozygote; 22 indicates wild-type homozygote; HWE, Hardy-Weinberg equilibrium; 3' UTR, three prime untranslated region; OR, odd ratios; CI, confidence interval.

ORs and P-values were for each case-control study separately under an additive model of inheritance.

^aOR with 95% CI in parentheses was adjusted for age, gender, body mass index, hypertension, alcohol use, total cholesterol, log (triglycerides), creatinine and hyperuricaemia by a logistic regression model.

^bPooled analysis was performed by the Cochran-Mantel-Haenszel test method using the PLINK v1.07. Three SNPs revealed homogeneity in the association with gout (Breslow-Day test, P > 0.33). OR with 95% CI in parentheses was adjusted for ethnicity, hyperuricaemia and other covariates using a logistic regression model.