Table 4.
Multivariable-adjusted RR (MVRR) and 95 % CI of breast cancer by receptor status for categories of intake of total milk and meat
| Type of breast cancer
|
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ER+
|
ER−
|
PR+
|
PR−
|
ER+/PR+
|
ER−/PR−
|
|||||||
| ncases | MVRR (95 % CI) | ncases | MVRR (95 % CI) | ncases | MVRR (95 % CI) | ncases | MVRR (95 % CI) | ncases | MVRR (95 % CI) | ncases | MVRR (95 % CI) | |
| Total milk (g/week) | ||||||||||||
| 0 | 110 | 1.00 (REF) | 73 | 1.00 (REF) | 81 | 1.00 (REF) | 96 | 1.00 (REF) | 78 | 1.00 (REF) | 69 | 1.00 (REF) |
| 1–69.9 | 65 | 0.96 (0.55–1.66) | 36 | 1.30 (0.57–2.96) | 55 | 1.04 (0.56–1.92) | 46 | 1.26 (0.62–2.58) | 54 | 1.25 (0.86,1.79) | 36 | 1.04 (0.67,1.59) |
| 70–124.9 | 30 | 0.65 (0.31–1.36) | 17 | 1.32 (0.52–3.36) | 21 | 0.53 (0.21–1.28) | 24 | 1.34 (0.59–3.00) | 21 | 0.97 (0.59,1.58) | 17 | 0.97 (0.55,1.68) |
| 125–249.9 | 47 | 0.65 (0.34–1.20) | 26 | 0.84 (0.34–2.07) | 39 | 0.65 (0.32–1.32) | 33 | 0.88 (0.40–1.92) | 38 | 1.00 (0.66,1.49) | 25 | 0.79 (0.48,1.27) |
| 250–499.9 | 52 | 0.70 (0.39–1.25) | 33 | 0.84 (0.35–2.01) | 41 | 0.69 (0.36–1.34) | 43 | 0.93 (0.44–1.94) | 38 | 0.84 (0.56,1.26) | 29 | 0.76 (0.48,1.20) |
| 500–749.9 | 27 | 0.56 (0.26–1.19) | 15 | 0.96 (0.35–2.58) | 21 | 0.56 (0.23–1.32) | 20 | 0.94 (0.39–2.23) | 21 | 1.00 (0.61,1.64) | 15 | 0.84 (0.47,1.50) |
| 750–999.9 | 45 | 0.71 (0.37–1.34) | 27 | 1.08 (0.44–2.63) | 37 | 0.69 (0.33–1.43) | 35 | 1.14 (0.52–2.45) | 35 | 1.08 (0.71,1.63) | 25 | 0.90 (0.55,1.46) |
| ≥1,000 | 106 | 0.85 (0.50–1.44) | 52 | 0.88 (0.39–1.99) | 84 | 0.80 (0.44–1.47) | 70 | 1.01 (0.50–2.02) | 81 | 1.16 (0.83,1.63) | 48 | 0.78 (0.52,1.16) |
| ptrend | 0.45 | 0.34 | 0.32 | 0.65 | 0.73 | 0.14 | ||||||
| Total meat (g/week) | ||||||||||||
| <400 | 91 | 1.00 (REF) | 47 | 1.00 (REF) | 68 | 1.00 (REF) | 70 | 1.00 (REF) | 68 | 1.00 (REF) | 47 | 1.00 (REF) |
| 400–599.9 | 93 | 0.94 (0.70–1.27) | 64 | 1.20 (0.81–1.75) | 85 | 1.15 (0.83–1.59) | 69 | 0.87 (0.62–1.22) | 81 | 1.09 (0.78,1.52) | 60 | 1.37 (0.74,2.51) |
| 600–799.9 | 98 | 1.12 (0.83–1.52) | 54 | 1.06 (0.70–1.59) | 77 | 1.19 (0.84–1.68) | 71 | 0.95 (0.67–1.34) | 73 | 1.13 (0.79,1.59) | 48 | 0.78 (0.38,1.59) |
| 800–999.9 | 77 | 1.20 (0.86–1.67) | 42 | 1.05 (0.67–1.64) | 56 | 1.18 (0.80–1.72) | 62 | 1.08 (0.74–1.56) | 54 | 1.13 (0.77,1.66) | 40 | 0.93 (0.44,1.95) |
| ≥1,000 | 123 | 1.20 (0.86–1.66) | 72 | 0.99 (0.63–1.54) | 93 | 1.22 (0.84–1.78) | 95 | 0.93 (0.64–1.36) | 90 | 1.18 (0.80,1.73) | 69 | 0.91 (0.44,1.86) |
| ptrend | 0.13 | 0.71 | 0.35 | 0.91 | 0.41 | 0.65 | ||||||
Multivariable relative risks (MVRRs) were adjusted for energy intake (quintiles), age at menarche (<12, 12–13, ≥14 years), body mass index (<25, 25–29, ≥30 kg/m2), family history of breast cancer (mother or sister), education (≤12, 13–15, ≥16 years), parity and age at first live birth (nulliparous, parity 1–2 and age at first birth <25 years, parity 1–2 and age at first birth 25–29 years, parity 1–2 and age at first birth ≥30 years, parity ≥3 and age at first birth <25 years, parity ≥3 and age at first birth 25–29 years, parity ≥3 and age at first birth ≥30 years), oral contraceptive use (yes/no), menopausal status (postmenopausal, premenopausal, and uncertain), age at menopause (<35, 35–39, 40–44, 45–49, 50–54, ≥55 years), menopausal hormone use (yes/no), vigorous physical activity (none, ≤2, >2 h/week), smoking status (never, former, current), and alcohol intake (none, 1–3, 4–6, ≥7 drinks/week)