Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: J Neuropathol Exp Neurol. 2013 Jul;72(7):614–623. doi: 10.1097/NEN.0b013e3182965886

TABLE 3.

Frequency and Severity of α-Synuclein-Positive Lesions in Pharyngeal Sensory Nerves in Patients With PD

ISLN
IX
PSB-X
Case No. LNs (range) Severity
of Lesions
LNs (range) Severity
of Lesions
LNs (range) Severity
of Lesions
PD 1 25 (18–31) ++ 13 (9–17) + 8 (3–14) +
PD 2 9 (6–13) + 4 (2–7) + 3 (1–7) +
PD 3 15 (10–22) + 10 (6–14) + 4 (2–6) +
PD 4 11 (7–15) + 0 0 0 0
PD 5 30 (20–39) ++ 18 (11–25) + 10 (5–16) +
PD 6 63 (56–68) +++ 25 (19–32) ++ 22 (12–34) ++
PD 7 8 (4–13) + 0 0 0 0
PD 8 22 (13–32) ++ 9 (5–14) + 6 (1–10) +
PD 9 13 (8–17) + 4 (2–7) + 0 0
PD 10 52 (43–59) +++ 23 (9–34) ++ 7 (4–11) +
Mean (range) 25 (8–63) 11 (0–25) 6 (0–22)

The severity of α-synuclein-positive lesions in the pharyngeal sensory nerves was rated on the basis of the mean density of the Lewy neurites (LNs) and assessed semiquantitatively using an arbitrary grading system: −, no lesions; +, 1–20 lesions/field (mild); ++, 21–50 lesions/field (moderate); +++, >50 lesions/field (severe). ISLN, internal superior laryngeal nerve; IX, glossopharyngeal nerve; PSB-X, pharyngeal sensory branch of the X nerve.