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. Author manuscript; available in PMC: 2013 Jun 28.
Published in final edited form as: Mol Cancer Ther. 2011 Jun 22;10(9):1591–1599. doi: 10.1158/1535-7163.MCT-10-0779

Table 1.

Physicochemical properties and pan-HDAC inhibition activities

Compound Carbon
linker (n)		 HDAC IC50
[nmol/L]		 PSA MW CLogP MV(Å)3 Excitation
(nm)		 Emission
(nm)
1 1 287 213.7 365.45 1.19 1,037.4 320 500
2 2 125 218.4 379.48 1.72 1,067.5 320 500
3 3 116 218.7 393.50 2.25 1,104.2 320 500
4 4 208 216.3 407.53 2.78 1,194.5 320 500
SAHA 80 180.1 264.32 0.99 868.7

NOTE: Compound structures are shown in Fig. 1.

Abbreviations: PSA, polar surface area; MW, molecular weight; CLogP, calculated log of the partition coefficient; MV, molecular volume; Excitation, excitation wavelength; Emission, emission wavelength.