Table 1.
Estimates of Key Quantities Describing Influenza Transmission in Baltimore, Maryland, During the 1918 Pandemic, as Inferred From the Best-Fitting Model
Quantity | Value or Estimate |
|||
No. | 95% CI | % | 95% CI | |
No. of households sampled | 6,753 | |||
No. of people included in sample | 28,977 | |||
No. of people reported as cases | 7,140 | |||
Overall attack rate for the fall wave | 24.6 | |||
Proportion of households reporting at least 1 case | 47.4 | |||
Secondary attack rate within affected households | 32.5 | |||
Proportion of cases which are asymptomatic and uninfectious | 0 | 0, 6 | ||
Proportion of cases which are asymptomatic and infectious | 0 | 0, 3 | ||
Dispersion parameter for individual variability in infectiousness (k; lower values correspond to more variability) | 0.94 | 0.59, 1.72 | ||
Scaling parameter for infectiousness as a function of household size (α, where in-house infectiousness decreases as 1/nα) | 0.35 | 0.22, 0.49 | ||
Effective reproduction no. (September 1–October 10), R | 1.38 | 1.33, 1.42 | ||
Basic reproduction no., R0 | 1.77 | 1.61, 1.95 | ||
Basic household reproduction no., R0* | 2.47 | 2.25, 2.73 | ||
Proportion of the population immune prior to September 1 | 22.2 | 17.1, 27.0 | ||
Reduction in reproduction no. on October 10 | 42.1 | 38.2, 45.7 | ||
Attack rate for a hypothetical scenario in which: | ||||
There was no prior immunity | 35.8 | |||
There was no reduction in R on October 10 | 44.9 | |||
There was neither immunity nor reduction in R | 74.2 |
Abbreviation: CI, confidence interval.