Fig. 1.

Clinical, immunological, virological and therapeutic history of the patient. The figure shows the clinical evolution we observed in our patient, from admission to death, according to the EDSS scale. We reported also the virological and immunological findings during hospitalisation. The arrows in the lower part of the figure represent the duration of HAART, mirtazapine and mefloquine experimental therapy and steroid treatment. JCV Q-PCR was performed on cerebrospinal fluid (CSF), plasma and urine samples and the JCV load is indicated in equivalent genome (gram equivalent per millimetre). Undet., HIV load <37 copies/ml in the CSF and plasma. Neg, negative. t0, 8 weeks after starting the rescue HAART (hospital admission); t1, 10 weeks after starting the rescue HAART (2 weeks after hospital admission); t2, 12 weeks after starting the rescue HAART (4 weeks after hospital admission); t3, 16 weeks after starting the rescue HAART (8 weeks after hospital admission)