Fig. 5.

ERG analysis of wild-type mice treated with AAV2/2-CBA-REP1 and AAV2/2-CBA-GFP. a Representative averaged ERG traces from the eyes injected with high-dose (1 × 10⁹ gp) AAV2/2-CBA-REP1 (shown in black) and AAV2/2-CBA-GFP (shown in grey). b, c Quantification of the amplitude of a- and b-waves (b) and implicit time data (c) recorded across a range of stimulus intensities in high-dose (1 × 10⁹ gp) AAV2/2-CBA-REP1-injected (filled black circles and solid black lines) and AAV2/2-CBA-GFP-injected (open grey circles and dashed grey lines) eyes. Plotted symbols show mean ± SEM, n = 5. d, e Quantification of the amplitude of a- and b-waves (d) and implicit time data (e) recorded across a range of stimulus intensities in low-dose (1 × 10⁸ gp) AAV2/2-CBA-REP1-injected (filled black circles and solid black lines) and AAV2/2-CBA-GFP-injected (open grey circles and dashed lines) eyes. Plotted symbols show mean ± SEM, n = 4