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. Author manuscript; available in PMC: 2013 Jul 3.
Published in final edited form as: Cell Metab. 2012 Jul 3;16(1):33–43. doi: 10.1016/j.cmet.2012.05.011

Figure 3. TLQP-21 enhances plasma insulin release and reduces glycemic excursion in male Wistar rats.

Figure 3

(A-C) Overnight (12 h) fasted rats were injected i.p. with either vehicle (saline) or TLQP-21 (4.5 mg/kg) at 30 min prior to an i.p. glucose (1 g/kg) bolus. (A) Blood glucose was monitored at the indicated times. (B) Average area under the curve (AUC) analysis for the glucose tolerance test results. (C) Blood was sampled from the saphenous vein at the indicated times and assayed for insulin levels. (D) Ad libitum fed rats were injected i.p. with saline, TLQP-21 (5 mg/kg) or TLQP-21 (1 mg/kg) at 30 min prior to an insulin (1 U/kg) challenge. Blood glucose was measured at the indicated times. Data represent the mean ± S.E.M (A-C, n = 12; D, n = 5). * p < 0.05, ** ≤ 0.01.