Table 1.
Cerebral Microcirculation Three Days After Transient MCAO at P10
Peak ΔR2* (ipsi/contra) |
Δtime-to peak (ipsi-contra) |
rCBV (ipsi/contra) |
ΔMTT (ipsi-contra) |
rCBF (ipsi/contra) |
|
---|---|---|---|---|---|
Caudate | 0.45±0.21 P = .012 |
0.80±0.60 | 0.56±0.13 P = .027 |
0.53±0.61 | 0.46±0.15 P = .005 |
Cortex | 0.74±0.18 P = .09 |
0.95±0.31 P = .033 |
0.89±0.13 | 0.78±0.21 P = .021 |
0.66±0.13 P = .081 |
Values for peak ΔR2*, relative cerebral blood volume and relative cerebral blood flow are ratios of values obtained from regions of interest in ipsilateral/contralateral. Δtime-to-peak and Δmean transit time values are the values measured in regions of interest (ipsilateral minus contralateral regions).
Animals showed reduced perfusion in the ipsilateral brain on dynamic imaging of bolus transit (n = 3). P values are obtained by t-test.
Abbreviations: CBV, cerebral blood volume, MCAO, middle cerebral artery obstruction; MTT, mean transit time, rCBF, regional blood flow volume; rCBV. regional cerebral blood volume.